Description

n-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Naphthalen-2-Yl)Methanesulfonamide is a high-purity, advanced pharmaceutical intermediate featuring a naphthalene core functionalized with a methanesulfonamide group and a pinacol boronate ester. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through versatile cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for the formation of carbon-carbon bonds in the synthesis of complex organic molecules and heterocycles.
• Pharmaceutical Intermediate: A crucial precursor in the research and development of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and material science applications.
• Polymer Chemistry: Employed as a monomer or functionalization agent in the synthesis of advanced polymeric materials with specific electronic or structural properties.
• Agrochemical Research: Acts as a building block for the development of new crop protection agents and herbicides.
• Material Science: Utilized in the creation of organic electronic materials, such as those for OLEDs or organic semiconductors.

Basic Information

Product Name	n-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Naphthalen-2-Yl)Methanesulfonamide
CAS No.	1132940-88-5
Molecular Formula	C₁₇H₂₂BNO₄S
Molecular Weight	347.24 g/mol
Synonyms	N-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-yl]methanesulfonamide; 2-Naphthalenesulfonamide, N-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-]; Methanesulfonamide, N-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthalenyl]-; 6-(N-Methanesulfonylamino)-2-naphthaleneboronic acid pinacol ester; 2-Naphthaleneboronic acid, 6-[(methylsulfonyl)amino]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our n-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Naphthalen-2-Yl)Methanesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your R&D and cGMP compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.