Description

Methyl 5-Bromo-2-(Difluoromethoxy)Benzoate is a high-purity, advanced pharmaceutical intermediate characterized by its bromine and difluoromethoxy functional groups. This compound is critical for medicinal chemists in the research and development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring specific halogen and fluorine substitutions. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical and agrochemical industries for synthesizing complex molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially in oncology, CNS, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of new-generation pesticides and herbicides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for specialty chemicals and advanced materials, including liquid crystals and organic electronic components.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex aromatic structures into target molecules.
• Fluorine Chemistry Studies: Acts as a valuable substrate for investigating the effects of fluorine atoms on molecular properties like lipophilicity and bioavailability.

Basic Information

Product Name	Methyl 5-Bromo-2-(Difluoromethoxy)Benzoate
CAS No.	1131587-78-4
Molecular Formula	C9H7BrF2O3
Molecular Weight	281.05 g/mol
Synonyms	5-Bromo-2-(difluoromethoxy)benzoic acid methyl ester; Methyl 5-bromo-2-(difluoromethoxy)benzoate; Benzoic acid, 5-bromo-2-(difluoromethoxy)-, methyl ester; 2-(Difluoromethoxy)-5-bromobenzoic acid methyl ester; Methyl 2-(difluoromethoxy)-5-bromobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-2-(Difluoromethoxy)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for sensitive R&D and scale-up processes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.