Description

6-(Difluoromethoxy)Pyridin-2-Amine is a high-value pyridine derivative featuring a difluoromethoxy substituent, a key structural motif in modern medicinal chemistry. This compound serves as a critical advanced pharmaceutical intermediate (API) for the synthesis of novel active ingredients. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing next-generation therapeutics, particularly in areas requiring fluorinated building blocks to modulate bioavailability and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) active pharmaceutical development.
• Agrochemical Research: Used in the discovery and synthesis of new-generation herbicides and pesticides, where the difluoromethoxy group can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic electronic materials.
• Ligand Synthesis: Employed in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: Acts as a model compound in academic and industrial research exploring the effects of fluorine substitution on chemical reactivity and physical properties.

Basic Information

Product Name	6-(Difluoromethoxy)Pyridin-2-Amine
CAS No.	1131007-43-6
Molecular Formula	C6H6F2N2O
Molecular Weight	160.12 g/mol
Synonyms	2-Amino-6-(difluoromethoxy)pyridine; 6-(Difluoromethoxy)-2-pyridinamine; 2-Pyridinamine, 6-(difluoromethoxy)-; 6-Amino-2-(difluoromethoxy)pyridine; 2-Amino-6-difluoromethoxypyridine; Difluoromethoxy-pyridin-2-yl-amine; 1131007-43-6
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethoxy)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR. We provide full traceability and Certificates of Analysis (COA) are available upon request to ensure compliance with your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.