Description

4-Bromo-3-Fluorobenzoic Acid Ethyl Ester is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its role as a versatile intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by R&D chemists and process development scientists for constructing active pharmaceutical ingredients (APIs), liquid crystal materials, and functional agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Active Ingredient Development: Used in the research and production of advanced herbicides and fungicides, where the bromo-fluoro substitution pattern is crucial for bioactivity.
• Liquid Crystal & OLED Material Synthesis: Serves as a precursor for fluorinated aromatic cores in electronic display and lighting materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Organic Synthesis Building Block: Utilized in academic and industrial research labs for constructing complex benzoic acid derivatives and heterocyclic compounds.
• Chemical Research & Development: Employed in method development and scale-up processes for fine chemical manufacturing.

Basic Information

Product Name	4-Bromo-3-Fluorobenzoic Acid Ethyl Ester
CAS No.	1130165-74-0
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	Ethyl 4-Bromo-3-fluorobenzoate; Benzoic acid, 4-bromo-3-fluoro-, ethyl ester; 3-Fluoro-4-bromobenzoic acid ethyl ester; 4-Bromo-3-fluorobenzoic acid ethyl ester; Ethyl 3-fluoro-4-bromobenzoate; 4-Bromo-3-fluoro-benzoic acid ethyl ester; 1130165-74-0
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Fluorobenzoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.