Description

tert-Butyl 5-Methoxy-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indole-piperidine scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with potential therapeutic applications. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) agents, receptor modulators, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Used in the construction of complex heterocyclic compounds and spirocyclic frameworks for academic and industrial research.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Biochemical Tool Compound: Potential use in probing biological pathways and protein interactions due to its specific structural features.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	tert-Butyl 5-Methoxy-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylate
CAS No.	1128137-43-8
Molecular Formula	C18H24N2O3
Molecular Weight	316.40 g/mol
Synonyms	1'-Boc-5-Methoxy-1,2-dihydrospiro[indole-3,4'-piperidine]; 5-Methoxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 5-methoxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 1,2-Dihydro-5-methoxyspiro[indole-3,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester; 1128137-43-8; Boc-5-methoxyspiroindolepiperidine; Spiro[indole-3,4'-piperidine]-1'-carboxylic acid, 1,2-dihydro-5-methoxy-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Methoxy-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.