Description

(R)-tert-Butyl 3-(5-Nitropyridin-2-Yloxy)Pyrrolidine-1-Carboxylate CAS NO 1126430-56-5 is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is of significant value for its role in the synthesis of complex, biologically active molecules, particularly in the development of new therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile building block for constructing complex molecular architectures in drug discovery programs.
• Process Chemistry & Scale-Up: Serves as a critical intermediate in the optimization and commercial-scale synthesis of target APIs.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce the (R)-configured pyrrolidine moiety into target molecules.
• Reference Standard: Supplied as a high-purity compound for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Item	Detail
Product Name	(R)-tert-Butyl 3-(5-Nitropyridin-2-Yloxy)Pyrrolidine-1-Carboxylate
CAS No.	1126430-56-5
Molecular Formula	C14H19N3O5
Molecular Weight	309.32 g/mol
Synonyms	(R)-1-Boc-3-(5-Nitro-2-pyridyloxy)pyrrolidine; (R)-tert-Butyl 3-((5-nitropyridin-2-yl)oxy)pyrrolidine-1-carboxylate; (R)-N-Boc-3-(5-Nitro-2-pyridyloxy)pyrrolidine; 1-(1,1-Dimethylethyl) (3R)-3-[(5-nitro-2-pyridinyl)oxy]-1-pyrrolidinecarboxylate; (R)-3-(5-Nitro-pyridin-2-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester; Boc-(R)-3-(5-Nitro-2-pyridyloxy)pyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 3-(5-Nitropyridin-2-Yloxy)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.