Description

5-(3-Chloro-2-Fluorophenyl)Pyridine-3-Carboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated pyridine-carboxamide structure. This compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers engaged in synthesizing complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging its halogenated aromatic system.
• Chemical Biology Probe: Serves as a core structure for creating molecular probes to study enzyme function and biological pathways.
• Material Science Precursor: Employed in the research of organic electronic materials and liquid crystals due to its rigid, conjugated framework.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	5-(3-Chloro-2-Fluorophenyl)Pyridine-3-Carboxamide
CAS No.	1125445-55-7
Molecular Formula	C12H8ClFN2O
Molecular Weight	250.66 g/mol
Synonyms	5-(3-Chloro-2-fluorophenyl)nicotinamide; 3-Pyridinecarboxamide, 5-(3-chloro-2-fluorophenyl)-; 5-(3-Chloro-2-fluorophenyl)-3-pyridinecarboxamide; 1125445-55-7; 5-(3-Chloro-2-fluoro-phenyl)-pyridine-3-carboxylic acid amide; 5-(3-Chloro-2-fluorophenyl)pyridine-3-carboxylic acid amide; 5-(3-Chloro-2-fluorophenyl)nicotinic acid amide
EINECS	Contact for details

Quality Control

Our production of 5-(3-Chloro-2-Fluorophenyl)Pyridine-3-Carboxamide adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates and can provide material suitable for research and non-GMP development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.