Description

n-(5-(Cyclopropylamino)-7-(Trifluoromethyl)-[1,2,4]Triazolo[1,5-A]Pyridin-2-Yl)Nicotinamide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers engaged in developing new therapeutic agents and crop protection solutions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Serves as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Development: Used in the research and synthesis of new-generation pesticides and herbicides, leveraging its triazolopyridine core.
• Biochemical Tool Compound: Employed in academic and industrial research as a probe to study specific biological pathways and enzyme inhibition.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.

Basic Information

Product Name	n-(5-(Cyclopropylamino)-7-(Trifluoromethyl)-[1,2,4]Triazolo[1,5-A]Pyridin-2-Yl)Nicotinamide
CAS No.	1124381-43-6
Molecular Formula	C16H13F3N6O
Molecular Weight	362.31 g/mol
Synonyms	N-[5-(Cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]pyridine-3-carboxamide; Nicotinamide, N-[5-(cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-; 1124381-43-6; UNII-9B3I4K5Q6C; 9B3I4K5Q6C; CHEMBL3185225; AKOS025147324; ZINC000253909996
EINECS	Contact for details

Quality Control

Every batch of n-(5-(Cyclopropylamino)-7-(Trifluoromethyl)-[1,2,4]Triazolo[1,5-A]Pyridin-2-Yl)Nicotinamide is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the exacting standards of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specification results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.