Description

tert-Butyl ((6-Bromopyridin-3-Yl)Methyl)(2-Methoxyethyl)Carbamate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for medicinal chemistry research and development, offering a protected amine functionality and a reactive bromopyridine moiety for further derivatization. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of small molecule drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its versatile chemical handles.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group provides a stable, acid-labile protecting group for amines during multi-step synthetic sequences.
• Cross-Coupling Reactions: The bromine atom on the pyridine ring serves as an excellent site for palladium-catalyzed cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination.
• Custom Synthesis: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom APIs for clinical trials.
• Chemical Library Development: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	tert-Butyl ((6-Bromopyridin-3-Yl)Methyl)(2-Methoxyethyl)Carbamate
CAS No.	1123837-28-4
Molecular Formula	C14H21BrN2O3
Molecular Weight	345.24 g/mol
Synonyms	Carbamic acid, N-[(6-bromo-3-pyridinyl)methyl]-N-(2-methoxyethyl)-, 1,1-dimethylethyl ester; tert-Butyl N-[(6-bromopyridin-3-yl)methyl]-N-(2-methoxyethyl)carbamate; 1,1-Dimethylethyl N-[(6-bromo-3-pyridinyl)methyl]-N-(2-methoxyethyl)carbamate; Boc-Protected 6-Bromo-3-(aminomethyl)pyridine Derivative; (6-Bromo-pyridin-3-ylmethyl)-(2-methoxy-ethyl)-carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl ((6-Bromopyridin-3-Yl)Methyl)(2-Methoxyethyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.