Description

tert-Butyl 3-Oxo-3H-Spiro[Isobenzofuran-1,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic structure. This compound is of significant value in modern organic synthesis, serving as a critical building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, particularly for projects targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those with spirocyclic or piperidine-based pharmacophores.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and scaffold diversification for discovering new bioactive molecules.
• API Development: Integral to the synthetic route of potential APIs targeting neurological and psychiatric conditions.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study biological pathways and protein functions.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule construction.

Basic Information

Product Name	tert-Butyl 3-Oxo-3H-Spiro[Isobenzofuran-1,4'-Piperidine]-1'-Carboxylate
CAS No.	1123492-82-9
Molecular Formula	C17H21NO4
Molecular Weight	303.35 g/mol
Synonyms	1'-Boc-3-oxo-3H-spiro[isobenzofuran-1,4'-piperidine]; tert-Butyl 3-oxospiro[isobenzofuran-1,4'-piperidine]-1'-carboxylate; 1,4'-Piperidine]-1'-carboxylic acid, 3-oxo-3H-spiro[isobenzofuran-1,4'-, 1,1-dimethylethyl ester; 3-Oxo-3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Boc-protected 3-oxospiro[isobenzofuran-1,4'-piperidine]; CAS 1123492-82-9
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Oxo-3H-Spiro[Isobenzofuran-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.