Description

Methyl 3,5-Difluoro-4-Nitrobenzoate is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is critical for modulating biological activity and metabolic stability. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate difluorinated nitrobenzoate motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-cancer agents, and CNS-active compounds.
• Agrochemical Synthesis: Serves as a key precursor in the development of next-generation herbicides, fungicides, and pesticides, where the fluorine atoms enhance lipophilicity and environmental stability.
• Material Science Research: Used in the synthesis of specialty polymers, liquid crystals, and advanced organic electronic materials that require fluorinated aromatic components.
• Chemical Biology & Proteomics: Employed as a reagent for creating chemical probes and affinity tags to study protein function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	Methyl 3,5-Difluoro-4-Nitrobenzoate
CAS No.	1123172-87-1
Molecular Formula	C8H5F2NO4
Molecular Weight	217.13 g/mol
Synonyms	3,5-Difluoro-4-nitrobenzoic acid methyl ester; Methyl 3,5-difluoro-4-nitrobenzoate; Benzoic acid, 3,5-difluoro-4-nitro-, methyl ester; 4-Nitro-3,5-difluorobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 3,5-Difluoro-4-Nitrobenzoate is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support regulatory filings. A detailed Certificate of Analysis (COA) documenting purity (typically ≥97% by HPLC), identity (by IR, NMR), and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. The compound is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.