Description

2-(1-Bromoethyl)-5-(Trifluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its unique trifluoromethyl and bromoethyl functional groups, which enable precise molecular modifications essential for developing novel materials and active ingredients. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating new drug candidates, crop protection agents, and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used as a precursor for novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand & Catalyst Development: Serves as a versatile scaffold for constructing complex ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of advanced organic electronic materials, liquid crystals, and polymers requiring specific halogenated motifs.
• Chemical Biology Probes: Useful for creating tagged molecules and activity-based probes for studying biological pathways and target engagement.
• Cross-Coupling Reactions: The bromoethyl side chain acts as an effective handle for Suzuki, Negishi, and other palladium-catalyzed cross-coupling reactions to build complex molecular architectures.

Basic Information

Product Name	2-(1-Bromoethyl)-5-(Trifluoromethyl)Pyridine
CAS No.	1122705-37-6
Molecular Formula	C8H7BrF3N
Molecular Weight	254.05 g/mol
Synonyms	5-(Trifluoromethyl)-2-(1-bromoethyl)pyridine; 2-(1-Bromoethyl)-5-(trifluoromethyl)pyridine; 1-(5-(Trifluoromethyl)pyridin-2-yl)ethyl bromide; α-Bromoethyl-5-trifluoromethylpyridine; 2-(α-Bromoethyl)-5-(trifluoromethyl)pyridine; 2-(Bromomethyl)ethyl-5-trifluoromethylpyridine (common misnomer); Pyridine, 2-(1-bromoethyl)-5-(trifluoromethyl)-; 1122705-37-6 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Every batch of 2-(1-Bromoethyl)-5-(Trifluoromethyl)Pyridine undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment includes adherence to in-house specifications developed for research and process chemistry applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from HPLC, NMR, and other critical tests to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.