Description

(R)-5-(Hydroxymethyl)-3-(2,3,5-Trifluoro-4-(4-Oxo-3,4-Dihydropyridin-1(2H)-Yl)Phenyl)Oxazolidin-2-One is a high-purity, non-racemic chiral building block and advanced pharmaceutical intermediate. This compound is of significant value for the development of novel therapeutic agents, particularly in the synthesis of complex, fluorine-containing active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the production of next-generation antibiotics and other specialized drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel antibacterial agents, particularly oxazolidinone-class antibiotics.
• API Synthesis: Used in the multi-step synthesis of complex, fluorinated active pharmaceutical ingredients (APIs) targeting resistant bacterial strains.
• Medicinal Chemistry Research: Serves as a critical building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed in chiral pool synthesis and catalytic asymmetric transformations due to its defined (R)-configuration.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes from laboratory to pilot and commercial production scales.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Product Name	(R)-5-(Hydroxymethyl)-3-(2,3,5-Trifluoro-4-(4-Oxo-3,4-Dihydropyridin-1(2H)-Yl)Phenyl)Oxazolidin-2-One
CAS No.	1112968-16-7
Molecular Formula	C16H14F3N2O4
Molecular Weight	355.29 g/mol
Synonyms	(R)-Tedizolid Intermediate; (R)-TR-700; (R)-5-(Hydroxymethyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one; (R)-5-(Hydroxymethyl)-3-[2,3,5-trifluoro-4-(4-oxo-1,2,3,4-tetrahydropyridin-1-yl)phenyl]oxazolidin-2-one; (R)-TR 700 FA; (R)-Tedizolid Phosphate Related Compound; (R)-Oxazolidinone Derivative; (R)-1,2,3,4-Tetrahydropyridin-4-one Derivative
EINECS	Contact for details

Quality Control

Our (R)-5-(Hydroxymethyl)-3-(2,3,5-Trifluoro-4-(4-Oxo-3,4-Dihydropyridin-1(2H)-Yl)Phenyl)Oxazolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.