Description

1H-Pyrrolo[2,3-B]Pyridine, 3-(1H-Indol-6-Yl)-1-[(4-Methylphenyl)Sulfonyl]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a sophisticated, high-purity boronic ester derivative designed for advanced synthetic chemistry. This compound serves as a critical building block in modern pharmaceutical research and development, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

This specialized boronic ester is a versatile intermediate with key applications in:

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and oncology research.
• Agrochemical Synthesis: Used in the development of new active ingredients with enhanced efficacy and environmental profiles.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and tool compounds for target identification and validation.
• Process Chemistry Development: Utilized for scaling up synthetic routes from laboratory to pilot plant scale under GMP-like conditions.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 3-(1H-Indol-6-Yl)-1-[(4-Methylphenyl)Sulfonyl]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1112948-62-5
Molecular Formula	C28H28BN3O4S
Molecular Weight	513.41 g/mol
Synonyms	3-(1H-Indol-6-yl)-1-[(4-methylphenyl)sulfonyl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1-Tosyl-3-(6-indolyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-azaindole; 5-Boronic acid pinacol ester derivative of 3-(6-indolyl)-1-tosyl-7-azaindole; 7-Azaindole boronic ester intermediate; Sulfonylated pyrrolopyridine boronate
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine derivative is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Production adheres to ISO 9001 quality management principles. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, NMR, and LC-MS. We support cGMP compliance for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.