Description

tert-Butyl 5-Bromo-2H,3H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a brominated pyrrolopyridine core protected by a Boc (tert-butoxycarbonyl) group. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in oncology and CNS (Central Nervous System) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for small-molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and synthesizing novel kinase inhibitors due to its privileged pyrrolopyridine structure.
• Chemical Biology Probes: Employed in the creation of chemical probes to study specific biological pathways and protein functions.
• Custom Synthesis: A versatile starting material for contract research and manufacturing organizations (CROs/CMOs) performing custom synthesis for clients.
• Library Synthesis: Used in the generation of diverse compound libraries for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	tert-Butyl 5-Bromo-2H,3H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate
CAS No.	1111638-13-1
Molecular Formula	C12H13BrN2O2
Molecular Weight	297.15 g/mol
Synonyms	1-Boc-5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester; tert-Butyl 5-bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 5-Bromo-1-(tert-butoxycarbonyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine; 1-Boc-5-bromo-1,2,3,4-tetrahydropyrrolo[2,3-b]pyridine; 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Bromo-2H,3H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific project requirements. We adhere to cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.