Description

3-(Difluoromethoxy)-2-Nitropyridine is a high-value, multi-functional heterocyclic building block characterized by its difluoromethoxy and nitro substituents. This compound is essential for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, liquid crystals, and functional polymers.
• Cross-Coupling Reactions: The nitro and halogen positions can be utilized in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex pyridine derivatives.
• Library Synthesis for Drug Discovery: Employed in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.
• Fluorine Chemistry Studies: Acts as a valuable substrate for studying the influence of the difluoromethoxy group on physicochemical properties like lipophilicity and metabolic profile.

Basic Information

Product Name	3-(Difluoromethoxy)-2-Nitropyridine
CAS No.	1111637-77-4
Molecular Formula	C6H4F2N2O3
Molecular Weight	190.10 g/mol
Synonyms	2-Nitro-3-(difluoromethoxy)pyridine; 3-(Difluoromethoxy)-2-nitropyridine; 2-Nitro-3-difluoromethoxypyridine; Pyridine, 3-(difluoromethoxy)-2-nitro-; 1111637-77-4
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)-2-Nitropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.