Description

1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-2,3-Dihydro-3-Methyl-1-(Phenylsulfonyl)- is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is of critical importance for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and agrochemical innovators seeking to develop new therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of kinase inhibitors and other small molecule drug candidates targeting various diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its modifiable bromo and sulfonyl functional groups.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, or insecticides with potential new modes of action.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Scale-Up: A critical starting material for contract manufacturers offering custom synthesis services from gram to kilogram scale.
• Academic Research: Employed in university and institutional labs for fundamental research in heterocyclic chemistry and new synthetic methodology development.

Basic Information

Item	Details
Product Name	1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-2,3-Dihydro-3-Methyl-1-(Phenylsulfonyl)-
CAS No.	1111637-64-9
Molecular Formula	C14H13BrN2O2S
Molecular Weight	353.23 g/mol
Synonyms	5-Bromo-2,3-dihydro-3-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-3-methyl-1-(phenylsulfonyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-2,3-dihydro-3-methyl-1-(phenylsulfonyl)-; 1111637-64-9; 5-Bromo-3-methyl-1-tosyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine (common alias); Brominated Dihydro Pyrrolopyridine Sulfonamide
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-2,3-Dihydro-3-Methyl-1-(Phenylsulfonyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.