Description

Propanenitrile, 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-Pyrrolo[2,3-B]Pyridin-5-Yl)-1H-Pyrazol-4-Yl]-2-Pyrimidinyl]Amino]- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value in the research and development of novel therapeutic agents, particularly in oncology and targeted disease pathways. It is primarily required by pharmaceutical R&D laboratories, biotechnology firms, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the synthesis of sophisticated small-molecule drug candidates.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of investigational new drugs, particularly kinase inhibitors.
• Oncology Research: Serves as a key precursor in the development of targeted cancer therapies due to its specific molecular scaffold.
• Biochemical Research: Used in academic and industrial research to study structure-activity relationships (SAR) and biological pathways.
• Pre-clinical Development: Essential for producing batches of active pharmaceutical ingredients (APIs) for pre-clinical toxicology and pharmacology studies.
• Process Chemistry: Employed in route scouting and optimization for scalable GMP (Good Manufacturing Practice) production.

Basic Information

Product Name	Propanenitrile, 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-Pyrrolo[2,3-B]Pyridin-5-Yl)-1H-Pyrazol-4-Yl]-2-Pyrimidinyl]Amino]-
CAS No.	1111636-35-1
Molecular Formula	C21H17F2N7
Molecular Weight	405.41 g/mol
Synonyms	3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-Pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile; 3-((4-(1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propanenitrile; 1111636-35-1; 3-[{4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino]propanenitrile; 3-({4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]pyrimidin-2-yl}amino)propanenitrile
EINECS	Contact for details

Quality Control

Our Propanenitrile, 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-Pyrrolo[2,3-B]Pyridin-5-Yl)-1H-Pyrazol-4-Yl]-2-Pyrimidinyl]Amino]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect this light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.