Description

6-Chloro-5-(Trifluoromethyl)Pyridine-3-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of a carboxylic acid handle, a chloro substituent, and a trifluoromethyl group, enabling precise molecular construction and the introduction of desirable physicochemical properties. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Serves as a critical building block for developing new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioactivity and environmental stability.
• Ligand & Catalyst Development: Used in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and other advanced synthetic methodologies.
• Material Science Research: Employed in the creation of functionalized pyridine derivatives for organic electronic materials, such as electron-transport layers or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	6-Chloro-5-(Trifluoromethyl)Pyridine-3-Carboxylic Acid
CAS No.	1110782-41-6
Molecular Formula	C7H3ClF3NO2
Molecular Weight	225.55 g/mol
Synonyms	6-Chloro-5-(trifluoromethyl)nicotinic acid; 3-Pyridinecarboxylic acid, 6-chloro-5-(trifluoromethyl)-; 6-Chloro-5-trifluoromethylpyridine-3-carboxylic acid; 6-Chloro-5-trifluoromethylnicotinic acid; 5-Trifluoromethyl-6-chloronicotinic acid; 1110782-41-6; 6-Chloro-5-(trifluoromethyl)-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-(Trifluoromethyl)Pyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.