Description

5-(3-Fluoro-4-Methylphenyl)Pyridin-2-Amine is a high-purity, advanced pharmaceutical intermediate with the CAS number 1110656-80-8. This compound is a critical building block in modern medicinal chemistry, valued for its unique structural motif that enables the synthesis of targeted therapeutic agents. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly in oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for investigational new drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Kinase Inhibitor Development: Serves as a core scaffold for creating potent and selective kinase inhibitors, a major class in oncology.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.
• Academic Research: Employed in university and institutional labs for cutting-edge chemical and pharmacological research.

Basic Information

Product Name	5-(3-Fluoro-4-Methylphenyl)Pyridin-2-Amine
CAS No.	1110656-80-8
Molecular Formula	C12H11FN2
Molecular Weight	202.23 g/mol
Synonyms	2-Amino-5-(3-fluoro-4-methylphenyl)pyridine; 5-(3-Fluoro-4-methylphenyl)-2-pyridinamine; 1110656-80-8; 2-Pyridinamine, 5-(3-fluoro-4-methylphenyl)-; 5-(3-Fluoro-p-tolyl)pyridin-2-amine
EINECS	Contact for details

Quality Control

Every batch of 5-(3-Fluoro-4-Methylphenyl)Pyridin-2-Amine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency essential for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.