Description

2-Amino-5-(4-Trifluoromethoxyphenyl)Pyridine is a high-value, multi-functional heterocyclic building block featuring a pyridine core substituted with an amino group and a trifluoromethoxy-phenyl moiety. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for enhanced lipophilicity and bioactivity.
• Material Science Research: Serves as a precursor for designing advanced organic electronic materials, ligands for metal-organic frameworks (MOFs), and specialty polymers.
• Chemical Biology & Proteomics: Employed as a building block for synthesizing molecular probes and activity-based protein profiling (ABPP) reagents.
• Ligand Synthesis in Catalysis: Utilized to create novel nitrogen-donor ligands for transition metal catalysts used in cross-coupling and other synthetic transformations.

Basic Information

Product Name	2-Amino-5-(4-Trifluoromethoxyphenyl)Pyridine
CAS No.	1110656-38-6
Molecular Formula	C13H11F3N2O
Molecular Weight	268.24 g/mol
Synonyms	5-(4-(Trifluoromethoxy)phenyl)pyridin-2-amine; 2-Amino-5-[4-(trifluoromethoxy)phenyl]pyridine; 2-Pyridinamine, 5-[4-(trifluoromethoxy)phenyl]-; 5-(4-Trifluoromethoxyphenyl)-2-aminopyridine; 2-Amino-5-(4-trifluoromethoxyphenyl)pyridine; 5-(4-(Trifluoromethoxy)phenyl)-2-pyridinamine
EINECS	Contact for details

Quality Control

Our 2-Amino-5-(4-Trifluoromethoxyphenyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.