Description

Pyridine, 2-[(4R,5S)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]- is a high-purity, chiral oxazoline-substituted pyridine derivative, serving as a sophisticated organocatalyst and chiral ligand in asymmetric synthesis. Its value lies in enabling precise stereochemical control for the production of enantiomerically pure pharmaceutical intermediates and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors who require reliable, high-performance building blocks for complex synthetic routes.

Application

• Asymmetric Catalysis: As a chiral ligand for transition metal complexes (e.g., with Cu, Pd, Rh) in enantioselective C-C and C-X bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Key building block for the development of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Organocatalysis: Direct use as an organocatalyst in stereoselective transformations such as aldol, Diels-Alder, or conjugate addition reactions.
• Agrochemical Research: Synthesis of chiral herbicides, fungicides, and plant growth regulators with enhanced biological activity.
• Material Science: Precursor for chiral polymers or coordination polymers with potential applications in sensors and chiral separation media.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and scale-up process optimization.

Basic Information

Product Name	Pyridine, 2-[(4R,5S)-4,5-Dihydro-4,5-Diphenyl-2-Oxazolyl]-
CAS No.	1108603-34-4
Molecular Formula	C20H16N2O
Molecular Weight	300.36 g/mol
Synonyms	(4R,5S)-4,5-Dihydro-4,5-diphenyl-2-(2-pyridinyl)-oxazole; (R,S)-2-(4,5-Dihydro-4,5-diphenyl-2-oxazolyl)pyridine; 2-[(4R,5S)-4,5-Diphenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine; Chiral Pyridine-Oxazoline Ligand; (R,S)-PyOx; (4R,5S)-2-(Pyridin-2-yl)-4,5-diphenyl-4,5-dihydrooxazole; 2-(4,5-Dihydro-4,5-diphenyl-2-oxazolyl)pyridine (stereoisomer)
EINECS	Contact for details

Quality Control

Our production of this advanced chiral chemical adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, chiral purity (ee%), and identity. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.