Description

5-Methoxy-n-Phenyl-4-(Trimethylsilyl)Nicotinamide is a specialized organosilicon-substituted nicotinamide derivative, serving as a high-value synthetic intermediate. Its unique structure, featuring both a methoxy and a trimethylsilyl group on the pyridine core, makes it a critical building block for advanced chemical synthesis. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly those targeting neurological and metabolic pathways.
• Organic Synthesis Building Block: Used in cross-coupling reactions, such as Suzuki or Stille couplings, facilitated by the reactive trimethylsilyl group.
• Ligand and Catalyst Development: Serves as a scaffold for creating novel ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Investigated for incorporation into advanced organic electronic materials due to its modified electron-donating properties.
• Agrochemical Research: Potential intermediate in the development of new generation pesticides and herbicides.
• Academic & R&D Laboratories: Employed in methodological studies and the exploration of new synthetic routes in peer-reviewed research.

Basic Information

Product Name	5-Methoxy-n-Phenyl-4-(Trimethylsilyl)Nicotinamide
CAS No.	1105675-62-4
Molecular Formula	C16H20N2O2Si
Molecular Weight	300.43 g/mol
Synonyms	4-(Trimethylsilyl)-5-methoxy-N-phenylnicotinamide; 5-Methoxy-4-(trimethylsilyl)-N-phenyl-3-pyridinecarboxamide; Nicotinamide, 5-methoxy-N-phenyl-4-(trimethylsilyl)-; 3-Pyridinecarboxamide, 5-methoxy-N-phenyl-4-(trimethylsilyl)-; 1105675-62-4; 5-Methoxy-N-phenyl-4-trimethylsilylnicotinamide
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our advanced intermediates. Each batch of 5-Methoxy-n-Phenyl-4-(Trimethylsilyl)Nicotinamide is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. Our quality system is designed to support cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.