Description

tert-Butyl 5-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a pinacol boronate ester group, making it a versatile building block for modern synthetic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, such as Suzuki-Miyaura couplings, which are critical for constructing complex molecular architectures in drug discovery and development. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality boronic acid derivatives for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety serves as a crucial coupling partner for forming carbon-carbon bonds with aryl or vinyl halides, a cornerstone of modern medicinal chemistry.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group protects the amine functionality, allowing for selective reactions elsewhere on the molecule during multi-step syntheses.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require complex pyridine-based structures.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, ligands for catalysts, and components in light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Can be utilized in the synthesis of molecular probes and bioconjugates for studying biological processes.

Basic Information

Product Name	tert-Butyl 5-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Ylcarbamate
CAS No.	1105675-61-3
Molecular Formula	C17H27BN2O5
Molecular Weight	350.22 g/mol
Synonyms	3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine, N-Boc-protected; tert-Butyl [5-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]carbamate; Boc-Protected 5-Methoxy-4-(pinacolboron)pyridin-3-amine; 4-Bpin-5-methoxy-pyridin-3-yl-carbamic acid tert-butyl ester; CAS 1105675-61-3; (5-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Ylcarbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and production use. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require storage under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.