Description

3-(4-Fluorophenyl)-2,4-Dioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylic Acid is a high-purity fluorinated pyrimidine derivative, a key advanced pharmaceutical intermediate (API) valued for its precise molecular architecture. This compound is critical for the research and synthesis of novel therapeutic agents, particularly in oncology and antiviral drug development. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in cutting-edge medicinal chemistry.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of complex active pharmaceutical ingredients (APIs), especially those targeting kinase inhibition.
• Medicinal Chemistry Research: Used as a scaffold or precursor in the discovery and optimization of new drug candidates, leveraging the fluorophenyl group for enhanced metabolic stability and binding affinity.
• Oncology Drug Development: A key intermediate for potential anti-cancer agents, where the pyrimidine-dione core is a common pharmacophore.
• Antiviral Compound Synthesis: Employed in the research and development of novel antiviral medications.
• Chemical Biology Probes: Used to create specialized probes for studying enzyme mechanisms and biological pathways in academic and industrial research settings.
• Custom Synthesis & Scale-Up: Supplied for custom synthesis projects requiring high-purity, structurally complex intermediates for pilot and commercial-scale production.

Basic Information

Product Name	3-(4-Fluorophenyl)-2,4-Dioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylic Acid
CAS No.	1105193-80-3
Molecular Formula	C11H7FN2O4
Molecular Weight	250.19 g/mol
Synonyms	5-Carboxy-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-2,4-pyrimidinedione; 3-(4-Fluorophenyl)-5-carboxy-1,2,3,4-tetrahydropyrimidine-2,4-dione; 3-(p-Fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid; 4-Fluorophenyl-dihydrouracil-5-carboxylic acid; Fluorinated Dihydrouracil Carboxylic Acid Derivative; API Intermediate 1105193-80-3; FP-DHPC Acid
EINECS	Contact for details

Quality Control

Our 3-(4-Fluorophenyl)-2,4-Dioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.