Description

The 3S, 5S Enantiomer Of Atorvastatin Calcium is a high-purity, single-enantiomer intermediate critical for the synthesis of advanced active pharmaceutical ingredients (APIs). This compound is essential for research and development in creating next-generation, stereochemically pure statin therapies. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and fine chemical synthesis specialists focused on cardiovascular drug development and chiral chemistry.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure Atorvastatin and its analogs.
• Active Pharmaceutical Ingredient (API) Research: Used in R&D for developing novel statin medications with improved efficacy and reduced side-effect profiles.
• Chiral Catalyst & Ligand Studies: Serves as a valuable substrate or precursor in asymmetric synthesis and catalysis research.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Metabolite Studies: Utilized in pharmacological and metabolic pathway research for cardiovascular drugs.
• Process Chemistry Development: Critical for scaling up and optimizing manufacturing processes for chiral pharmaceuticals.

Basic Information

Product Name	3S, 5S Enantiomer Of Atorvastatin Calcium
CAS No.	1105067-88-6
Molecular Formula	C66H68CaF2N4O10
Molecular Weight	1155.34 g/mol
Synonyms	Atorvastatin Calcium (3S,5S) Enantiomer; (3S,5S)-Atorvastatin Calcium Salt; (3R,5R)-Atorvastatin Calcium (enantiomer); (βR,δR)-Atorvastatin Calcium; Enantiomer of Atorvastatin Calcium; Single-Enantiomer Atorvastatin Calcium; Lipitor Enantiomer Intermediate; (3S,5S)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Calcium Salt
EINECS	Contact for details

Quality Control

Our 3S, 5S Enantiomer Of Atorvastatin Calcium is manufactured under strict quality systems. Each batch is tested to ensure high enantiomeric purity and chemical identity, aligning with ICH guidelines for pharmaceutical intermediates. Comprehensive testing includes chiral HPLC for enantiomeric excess, assay, and control of related substances. A Certificate of Analysis (COA) documenting all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.