Description

2-Pyridin-2-Yl-Malonic Acid Di-tert-Butyl Ester is a high-purity, protected malonic acid derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the tert-butyl ester protecting groups, which provide excellent stability and selectivity during complex multi-step synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex heterocyclic scaffolds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those containing pyridine and malonate pharmacophores.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides requiring specific heterocyclic structures.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions, such as Suzuki or Heck reactions, for carbon-carbon bond formation.
• Ligand Precursor: Serves as a starting material for the preparation of specialized bidentate or tridentate ligands used in catalysis.
• Material Science Research: Utilized in the development of organic electronic materials and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-Pyridin-2-Yl-Malonic Acid Di-tert-Butyl Ester
CAS No.	1104643-39-1
Molecular Formula	C₁₇H₂₅NO₄
Molecular Weight	307.39 g/mol
Synonyms	Di-tert-butyl 2-(pyridin-2-yl)malonate; 2-(Pyridin-2-yl)malonic Acid Di-tert-butyl Ester; Di-tert-butyl 2-pyridin-2-ylpropanedioate; 2-Pyridylmalonic Acid Di-tert-butyl Ester; Propanedioic acid, 2-(2-pyridinyl)-, 1,3-bis(1,1-dimethylethyl) ester; 1104643-39-1; 2-(2-Pyridyl)malonic Acid Di-tert-butyl Ester
EINECS	Contact for details

Quality Control

Every batch of 2-Pyridin-2-Yl-Malonic Acid Di-tert-Butyl Ester is produced and tested under strict quality management systems to ensure consistency and reliability for your critical synthesis work. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our standard quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and documentation for regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the original container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.