Description

1-Piperidinecarboxylic Acid, 3-Hydroxy-3-Methyl-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic pathways. It is primarily sought by research institutions and manufacturers in the global pharmaceutical and fine chemical industries for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially for central nervous system (CNS) and metabolic disorder treatments.
• Protease Inhibitor Synthesis: Used in the research and development of protease inhibitors, a major class of antiviral and anticancer drugs.
• Peptidomimetic Chemistry: Serves as a constrained amino acid analog for constructing peptidomimetics, which are designed to mimic peptides but with improved stability and bioavailability.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Bioconjugation & Linker Chemistry: Potential use in creating cleavable linkers for antibody-drug conjugates (ADCs) or other targeted drug delivery systems.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 3-Hydroxy-3-Methyl-, 1,1-Dimethylethyl Ester
CAS No.	1104083-27-3
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	tert-Butyl 3-Hydroxy-3-methylpiperidine-1-carboxylate; 3-Hydroxy-3-methyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 3-Hydroxy-3-methylpiperidine-1-carboxylic acid tert-butyl ester; Boc-3-Hydroxy-3-methylpiperidine; 1-Boc-3-Hydroxy-3-methylpiperidine; 1-(tert-Butoxycarbonyl)-3-hydroxy-3-methylpiperidine; 3-Methyl-3-hydroxypiperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarboxylic Acid, 3-Hydroxy-3-Methyl-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. We provide material suitable for research and development use, with typical purity grades exceeding 97% (by HPLC). Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. For cGMP-grade material intended for pharmaceutical applications, please contact our technical sales team for specific qualification data and regulatory support documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.