Description

6-Azaspiro[2.5]Octane-6-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester, (4S)- is a high-value, stereochemically defined building block of significant interest in advanced organic synthesis. Its unique spirocyclic and heterocyclic architecture makes it a critical intermediate for constructing complex molecular frameworks with precise three-dimensional control. This compound is primarily utilized by pharmaceutical and biotechnology R&D teams focused on developing novel active pharmaceutical ingredients (APIs), particularly in areas requiring constrained peptidomimetics and targeted small molecule therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and metabolic disease targets.
• Peptidomimetic Scaffold: Used to design and synthesize conformationally restricted peptide analogs, enhancing metabolic stability and receptor selectivity.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore novel chemical space and optimize lead compound properties.
• Chemical Biology Probe Development: Acts as a core structure for creating tool compounds to study biological pathways and protein function.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in stereoselective synthesis protocols to introduce complex spirocyclic motifs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex intermediates for clinical trial materials.

Basic Information

Product Name	6-Azaspiro[2.5]Octane-6-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester, (4S)-
CAS No.	1101840-73-6
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	(4S)-4-Hydroxy-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester; tert-Butyl (4S)-4-hydroxy-6-azaspiro[2.5]octane-6-carboxylate; (S)-tert-Butyl 4-hydroxy-6-azaspiro[2.5]octane-6-carboxylate; 6-Boc-4-hydroxy-6-azaspiro[2.5]octane (S-enantiomer); (S)-4-Hydroxy-6-((tert-butoxycarbonyl)amino)spiro[2.5]octane; Spirocyclic β-amino acid derivative; Chiral azaspirooctane building block
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and enantiomeric purity suitable for demanding R&D and pre-clinical applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.