Description

tert-Butyl 1-Amino-7-Azaspiro[3.5]Nonane-7-Carboxylate Hcl CAS NO 1100748-78-4 is a high-purity, protected spirocyclic amine building block essential for modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of complex molecules, offering a rigid, three-dimensional scaffold that is highly valued in drug discovery for modulating biological activity and improving pharmacokinetic properties. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained spirocyclic structure.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scalable synthesis of candidate drugs under Good Manufacturing Practice (GMP) conditions.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed in the construction of linkers and warhead components for targeted protein degradation therapeutics.
• Chemical Biology: Utilized as a scaffold for developing chemical probes to study enzyme function and protein-protein interactions.
• Library Synthesis: A valuable reagent for generating diverse compound libraries for high-throughput screening (HTS) in early-stage drug discovery.

Basic Information

Item	Details
Product Name	tert-Butyl 1-Amino-7-Azaspiro[3.5]Nonane-7-Carboxylate Hydrochloride
CAS No.	1100748-78-4
Molecular Formula	C13H25ClN2O2
Molecular Weight	276.80 g/mol
Synonyms	1-Amino-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester hydrochloride; 7-(tert-Butoxycarbonyl)-1-amino-7-azaspiro[3.5]nonane hydrochloride; tert-Butyl 1-amino-7-azaspiro[3.5]nonane-7-carboxylate hydrochloride; 1-Amino-7-Boc-7-azaspiro[3.5]nonane HCl; Boc-1-Amino-7-azaspiro[3.5]nonane HCl; 7-Azaspiro[3.5]nonane-7-carboxylic acid, 1-amino-, 1,1-dimethylethyl ester, hydrochloride; 1100748-78-4
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Amino-7-Azaspiro[3.5]Nonane-7-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring material for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.