Description

(1S,2S)-Threo-Honokitriol is a specific stereoisomer of the natural lignan honokitriol, derived from the *Magnolia* species. This compound is valued for its high purity and defined stereochemistry, which is critical for precise pharmacological and biochemical research. It serves as a key reference standard and intermediate for researchers and manufacturers in the pharmaceutical, nutraceutical, and advanced organic synthesis sectors.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of honokitriol and related compounds in drug development and quality control.
• Bioactive Compound Research: Serves as a pure standard in studies investigating the anti-inflammatory, neuroprotective, or anxiolytic properties of magnolia-derived lignans.
• Natural Product Synthesis: Acts as a chiral building block or intermediate in the total synthesis of complex natural products and analogs.
• Nutraceutical Standardization: Employed to standardize and authenticate botanical extracts, particularly those from *Magnolia officinalis*, for dietary supplements.
• Metabolite Studies: Utilized in pharmacokinetic and metabolic pathway research to identify and quantify honokitriol metabolites.

Basic Information

Product Name	(1S,2S)-Threo-Honokitriol
CAS No.	1099687-80-5
Molecular Formula	C18H18O6
Molecular Weight	330.33 g/mol
Synonyms	(-)-Threo-Honokitriol; (1S,2S)-Honokitriol; Honokitriol (Threo-isomer); Magnolia Lignan; (8R,8'R,9S)-4,4'-Dihydroxy-3,3',5,5'-tetramethoxy-9,9'-epoxylignan-7,7'-diol; (1S,2S)-4,4'-Dihydroxy-3,3',5,5'-tetramethoxy-9,9'-epoxylignan-7,7'-diol
EINECS	Contact for details

Quality Control

Our (1S,2S)-Threo-Honokitriol is produced under strict quality management protocols. Each batch is characterized and tested to ensure identity, purity, and stereochemical integrity, meeting the stringent requirements for research and reference materials. A comprehensive Certificate of Analysis (COA) detailing results from HPLC, NMR, and optical rotation tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound should be handled under inert atmosphere for long-term storage to prevent potential oxidation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Specific range provided on COA
Heavy Metals	< 10 ppm
Residual Solvents	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.