Description

2,3-Bis-(Trifluoromethyl)-1,8-Naphthyridine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique electronic and steric properties imparted by the two trifluoromethyl groups, which are critical for modulating the physicochemical characteristics of target molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly where enhanced metabolic stability, lipophilicity, or bioavailability is required.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex drug candidates, especially in kinase inhibitor and antiviral research programs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the fluorine atoms for improved efficacy and environmental profile.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as electron-transport layers in OLEDs or semiconductors, due to its electron-deficient naphthyridine core.
• Ligand Synthesis: Utilized in the preparation of specialized ligands for catalysis, where the trifluoromethyl groups can fine-tune metal-binding properties.
• Fluorine Chemistry Library Building: An essential component for creating diverse compound libraries in medicinal and discovery chemistry focused on fluorinated analogs.

Basic Information

Product Name	2,3-Bis-(Trifluoromethyl)-1,8-Naphthyridine
CAS No.	1099597-87-1
Molecular Formula	C12H4F6N2
Molecular Weight	290.17 g/mol
Synonyms	2,3-Bis(trifluoromethyl)-1,8-naphthyridine; 1,8-Naphthyridine, 2,3-bis(trifluoromethyl)-; 2,3-Di(trifluoromethyl)-1,8-naphthyridine; BTN; 2,3-Bis(trifluoromethyl)naphthyridine; 2,3-Bis(trifluoromethyl)-1,8-diazanaphthalene
EINECS	Contact for details

Quality Control

Our 2,3-Bis-(Trifluoromethyl)-1,8-Naphthyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF for moisture content, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.