Description

1-(Trifluoroacetyl)Piperidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold functionalized with both a trifluoroacetyl group and a carboxylic acid. This compound is of significant value for medicinal chemistry research and development, offering versatile synthetic handles for constructing complex molecules. It is primarily sought after by R&D teams in the pharmaceutical and agrochemical industries for applications in drug discovery, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its modifiable piperidine core and functional groups.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced crop protection agents and pesticides.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions.
• Academic Research: Employed in university and institutional labs for methodological development and novel heterocyclic chemistry.

Basic Information

Item	Details
Product Name	1-(Trifluoroacetyl)Piperidine-3-Carboxylic Acid
CAS No.	1099017-20-5
Molecular Formula	C8H10F3NO3
Molecular Weight	225.17 g/mol
Synonyms	3-Piperidinecarboxylic acid, 1-(trifluoroacetyl)-; 1-Trifluoroacetylpiperidine-3-carboxylic acid; 1-(2,2,2-Trifluoroacetyl)piperidine-3-carboxylic acid; Piperidine-3-carboxylic acid, 1-(trifluoroacetyl)-; 1099017-20-5; 1-TFAPCA; 1-(Trifluoroacetyl)-3-piperidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1-(Trifluoroacetyl)Piperidine-3-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the high standards required for pharmaceutical R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.