Description

8-Fluoro-5-Methyl-2,3,4,5-Tetrahydro-1H-Pyrido[4,3-B]Indole is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of central nervous system (CNS) and oncology drug discovery. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in synthesizing complex bioactive molecules. The precise fluorination and methylation pattern on this fused ring system make it a valuable building block for medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel drug candidates targeting neurological disorders.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies in academic and industrial R&D.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of potential APIs, particularly those with indole- and tetrahydro-β-carboline-based structures.
• Biochemical Tool Compound: Utilized in pharmacological assays to study receptor binding affinity and enzyme inhibition.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	8-Fluoro-5-Methyl-2,3,4,5-Tetrahydro-1H-Pyrido[4,3-B]Indole
CAS No.	1095263-80-1
Molecular Formula	C₁₂H₁₃FN₂
Molecular Weight	204.24 g/mol
Synonyms	8-Fluoro-5-methyl-1,2,3,4,5,6-hexahydropyrido[4,3-b]indole; 5-Methyl-8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; 1,2,3,4-Tetrahydro-8-fluoro-5-methylpyrido[4,3-b]indole; 8-Fluoro-5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; Fluoro-methyl-tetrahydro-pyridoindole; Fused tetrahydro-β-carboline derivative
EINECS	Contact for details

Quality Control

Our 8-Fluoro-5-Methyl-2,3,4,5-Tetrahydro-1H-Pyrido[4,3-B]Indole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Specifications are designed to meet the stringent needs of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.