Description

1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylic Acid, 3-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester is a high-value pharmaceutical intermediate and building block of significant interest in modern organic synthesis. Its core value lies in its functionalized pyrazolopyridine scaffold, which is a privileged structure in medicinal chemistry for developing novel bioactive compounds. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly for targeting kinase-related pathways.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially kinase inhibitors.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new drug candidates.
• Chemical Biology Probes: Serves as a core scaffold for creating molecular probes to study biological pathways and enzyme functions.
• Custom Synthesis: Employed in contract research and manufacturing (CRAM) for bespoke chemical synthesis projects.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and pesticides.

Basic Information

Product Name	1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylic Acid, 3-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester
CAS No.	1095223-35-0
Molecular Formula	C13H17N3O3
Molecular Weight	263.29 g/mol
Synonyms	tert-Butyl 3-(hydroxymethyl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)-1H-pyrazolo[3,4-b]pyridine; 3-(Hydroxymethyl)-1H-pyrazolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester; Boc-3-hydroxymethyl-1H-pyrazolo[3,4-b]pyridine; 1-Boc-3-hydroxymethyl-1H-pyrazolo[3,4-b]pyridine; Pyrazolo[3,4-b]pyridine-1-carboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylic Acid, 3-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) with full specification data are provided for all shipments. We support development and cGMP-grade production to meet the stringent requirements of pharmaceutical research and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.