Description

Ethyl 1-Cbz-5-Hydroxypiperidine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine scaffold protected by a carboxybenzyl (Cbz) group. This compound is critical for medicinal chemists in the research and development of novel therapeutic agents, particularly as a key building block for complex molecules. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors for synthesizing active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Protease Inhibitor Synthesis: The protected piperidine structure is valuable for constructing core scaffolds in protease inhibitor development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Employed in university and institutional labs for organic synthesis methodology development and bioorganic chemistry.

Basic Information

Product Name	Ethyl 1-Cbz-5-Hydroxypiperidine-3-Carboxylate
CAS No.	1095010-49-3
Molecular Formula	C16H21NO5
Molecular Weight	307.34 g/mol
Synonyms	Ethyl 1-[(benzyloxy)carbonyl]-5-hydroxypiperidine-3-carboxylate; 1-Cbz-5-Hydroxypiperidine-3-carboxylic Acid Ethyl Ester; 5-Hydroxy-1-[(phenylmethoxy)carbonyl]-3-piperidinecarboxylic Acid Ethyl Ester; Ethyl 5-Hydroxy-1-[(phenylmethoxy)carbonyl]piperidine-3-carboxylate; 1-N-Cbz-5-Hydroxynipecotic Acid Ethyl Ester; Ethyl 1-(Benzyloxycarbonyl)-5-hydroxypiperidine-3-carboxylate; 3-Carbethoxy-5-hydroxy-1-Cbz-piperidine
EINECS	Contact for details

Quality Control

Our Ethyl 1-Cbz-5-Hydroxypiperidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.