Description

Methyl 1-Boc-5-Hydroxypiperidine-3-Carboxylate is a high-purity, protected piperidine derivative serving as a critical chiral building block in advanced organic synthesis. This compound is essential for constructing complex molecular architectures, offering precise control over stereochemistry and functional group compatibility. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of piperidine-based drug candidates, including potential central nervous system (CNS) agents and enzyme inhibitors.
• Peptidomimetics & Scaffold Development: Used in medicinal chemistry to create constrained peptide analogs and novel heterocyclic scaffolds for drug discovery programs.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides and fungicides with specific chiral activity.
• Asymmetric Catalysis Ligand Precursor: Employed in the preparation of chiral ligands and organocatalysts for stereoselective transformations.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules on scale.
• Academic & Industrial Research: Used in research laboratories for methodological studies in organic synthesis and the exploration of new chemical entities.

Basic Information

Product Name	Methyl 1-Boc-5-Hydroxypiperidine-3-Carboxylate
CAS No.	1095010-47-1
Molecular Formula	C13H23NO5
Molecular Weight	273.32 g/mol
Synonyms	1-Boc-5-Hydroxypiperidine-3-carboxylic Acid Methyl Ester; Methyl 5-Hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-3-carboxylate; tert-Butyl 5-Hydroxy-3-(methoxycarbonyl)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-5-hydroxypiperidine-3-carboxylic Acid Methyl Ester; Methyl 1-(tert-Butoxycarbonyl)-5-hydroxypiperidine-3-carboxylate; 5-Hydroxy-1-N-Boc-piperidine-3-carboxylic Acid Methyl Ester; 1-Boc-5-Hydroxy-3-piperidinecarboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 1-Boc-5-Hydroxypiperidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.