Description

1-(6-Bromopyridin-2-Yl)Cyclopropanecarbonitrile is a high-value brominated pyridine derivative and cyclopropane-containing building block, essential for advanced organic synthesis. Its unique structure, featuring both a bromine substituent and a nitrile-functionalized cyclopropane ring, makes it a critical intermediate for constructing complex molecular architectures with precise spatial control. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, ligand synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the discovery and synthesis of novel herbicides, fungicides, and insecticides, leveraging its halogenated heterocyclic core.
• Ligand & Catalyst Development: Serves as a precursor for creating sophisticated ligands in transition metal catalysis and organocatalysis.
• Material Science Precursor: Employed in the research of advanced organic electronic materials and functional polymers.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Medicinal Chemistry SAR Studies: The rigid cyclopropane and modifiable nitrile group are utilized in structure-activity relationship (SAR) explorations to optimize drug-like properties.

Basic Information

Product Name	1-(6-Bromopyridin-2-Yl)Cyclopropanecarbonitrile
CAS No.	1093879-77-6
Molecular Formula	C9H7BrN2
Molecular Weight	223.07 g/mol
Synonyms	1-(6-Bromo-2-pyridinyl)cyclopropanecarbonitrile; Cyclopropanecarbonitrile, 1-(6-bromo-2-pyridinyl)-; 1-(6-Bromopyridin-2-yl)cyclopropane-1-carbonitrile; 2-(1-Cyanocyclopropyl)-6-bromopyridine; 6-Bromo-2-(1-cyanocyclopropyl)pyridine; 1-(6-Bromopyridin-2-yl)cyclopropanecarbonitrile; 1093879-77-6
EINECS	Contact for details

Quality Control

Our 1-(6-Bromopyridin-2-Yl)Cyclopropanecarbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most sensitive R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.