Description

2-[1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-1-Methylethyl]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolapyridine is a high-value, protected boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling complex cross-coupling reactions, particularly Suzuki-Miyaura couplings, with high selectivity and yield. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific pyridine-based structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugation reagents for studying biological systems.
• Academic & R&D Laboratories: A vital reagent for methodological development in synthetic organic chemistry and catalysis studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and small-molecule libraries.

Basic Information

Product Name	2-[1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-1-Methylethyl]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolapyridine
CAS No.	1093878-52-4
Molecular Formula	C20H34BNO3Si
Molecular Weight	375.39 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[1-[(tert-butyldimethylsilyl)oxy]-1-methylethyl]pyridine; 2-(1-((tert-Butyldimethylsilyl)oxy)-1-methylethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; TBS-protected pyridine boronic ester; tert-Butyldimethylsilyl 2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)propan-2-yl ether; Pinacol boronate pyridine derivative; CAS 1093878-52-4
EINECS	Contact for details

Quality Control

Our 2-[1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-1-Methylethyl]-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolapyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including NMR (1H, 13C, 11B), HPLC, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening the container for use to prevent degradation. For long-term storage, consider storing under an inert gas blanket in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.