Description

3-Difluoromethylpiperidine Hcl CAS NO 1093759-69-3 is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethyl-substituted piperidine scaffold. This compound is of significant commercial interest for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring enhanced metabolic stability and bioavailability. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the difluoromethyl group can improve biological activity.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and lead optimization.
• Ligand and Catalyst Development: Potential use in creating specialized ligands for catalysis or as a component in organofluorine chemistry research.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	3-Difluoromethylpiperidine Hydrochloride
CAS No.	1093759-69-3
Molecular Formula	C7H14ClF2N
Molecular Weight	185.64 g/mol
Synonyms	3-(Difluoromethyl)piperidine hydrochloride; Piperidine, 3-(difluoromethyl)-, hydrochloride (1:1); 3-Difluoromethylpiperidine HCl; 3-(Difluoromethyl)piperidine HCl; 1093759-69-3; 3-Difluoromethyl-piperidine hydrochloride; 3-Difluoromethylpiperidine Hydrochloride Salt
EINECS	Contact for details

Quality Control

Our 3-Difluoromethylpiperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.