Description

Methyl 6,6-Difluorobicyclo[3.1.0]Hexane-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique strained bicyclic scaffold with strategic fluorine substitution. This compound is valued for its role in modulating the physicochemical and metabolic properties of target molecules, making it a critical building block in modern drug discovery. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluorinated bicyclic structure can enhance bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for specialty monomers or ligands in the development of novel polymers and functional materials.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization to improve potency, selectivity, and pharmacokinetic profiles.
• Fluorine Chemistry: A valuable reagent for introducing fluorinated, strained-ring systems into complex molecular architectures.

Basic Information

Product Name	Methyl 6,6-Difluorobicyclo[3.1.0]Hexane-3-Carboxylate
CAS No.	1093750-99-2
Molecular Formula	C9H12F2O2
Molecular Weight	190.19 g/mol
Synonyms	Methyl 6,6-difluorobicyclo[3.1.0]hexane-3-carboxylate; 6,6-Difluorobicyclo[3.1.0]hexane-3-carboxylic acid methyl ester; Bicyclo[3.1.0]hexane-3-carboxylic acid, 6,6-difluoro-, methyl ester; Methyl 6,6-difluoro-3-bicyclo[3.1.0]hexanecarboxylate
EINECS	Contact for details

Quality Control

Every batch of Methyl 6,6-Difluorobicyclo[3.1.0]Hexane-3-Carboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and scale-up activities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids/organic solvents and fluorides/strong alkalis.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.