Description

1-[Tris(1-Methylethyl)Silyl]-1H-Pyrrolo[2,3-B]Pyridine-4-Carbonitrile is a high-value, organosilicon-protected pyrrolopyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary commercial value lies in enabling the efficient and selective construction of complex nitrogen-containing heterocycles, which are core scaffolds in modern pharmaceuticals. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel kinase inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization in medicinal chemistry and material science.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new chemical space in heterocyclic chemistry.
• Protecting Group Strategy: The tris(isopropyl)silyl (TIPS) group provides steric protection for sensitive nitrogen sites during multi-step syntheses.

Basic Information

Product Name	1-[Tris(1-Methylethyl)Silyl]-1H-Pyrrolo[2,3-B]Pyridine-4-Carbonitrile
CAS No.	1092580-01-2
Molecular Formula	C18H25N3Si
Molecular Weight	311.50 g/mol
Synonyms	1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile; 4-Cyano-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, 1-[tris(1-methylethyl)silyl]-; TIPS-Pyrrolopyridine-4-carbonitrile; 1-TIPS-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile; CAS 1092580-01-2
EINECS	Contact for details

Quality Control

Our 1-[Tris(1-Methylethyl)Silyl]-1H-Pyrrolo[2,3-B]Pyridine-4-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be sensitive to moisture and should be handled under inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.