Description

4-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functional heterocyclic building block featuring a fused pyrrolopyridine core substituted with a trifluoromethyl group. This compound is strategically important for its ability to impart metabolic stability, lipophilicity, and electronic properties to advanced molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, receptor modulators, and other small-molecule drug candidates targeting oncology, CNS disorders, and inflammatory diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as ligands for OLEDs or charge-transport materials, due to its conjugated π-system and electron-withdrawing substituent.
• Chemical Biology Probe: Employed in the design of fluorescent tags, photoaffinity labels, or molecular probes to study biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for bespoke synthesis projects requiring complex, fluorinated heterocycles.

Basic Information

Product Name	4-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1092579-96-8
Molecular Formula	C8H5F3N2
Molecular Weight	186.14 g/mol
Synonyms	4-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-(trifluoromethyl)-; 4-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine; 4-(Trifluoromethyl)-7-azaindole; 4-CF3-7-azaindole; 4-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1092579-96-8
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF for moisture content, to ensure it meets the high standards required for research and scale-up. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.