Description

6-Chloro-2-(Ethylamino)Pyridine-3-Carbonyl Fluoride is a high-value, fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a reactive carbonyl fluoride group and a chloro-substituted pyridine ring, makes it an essential intermediate for constructing complex molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the pyridine core for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Fluorination Chemistry: The carbonyl fluoride moiety acts as a versatile fluorinating agent or handle for introducing fluorine atoms into target molecules, a common strategy in medicinal chemistry to modulate metabolic stability and bioavailability.
• Cross-Coupling Reactions: The chloro substituent provides a site for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), enabling rapid diversification of molecular scaffolds.
• Ligand and Catalyst Development: Employed in the synthesis of novel nitrogen-containing ligands for metal catalysis and organocatalysts.

Basic Information

Product Name	6-Chloro-2-(Ethylamino)Pyridine-3-Carbonyl Fluoride
CAS No.	1092523-22-2
Molecular Formula	C9H8ClFN2O
Molecular Weight	214.62 g/mol
Synonyms	2-(Ethylamino)-6-chloropyridine-3-carbonyl fluoride; 6-Chloro-2-(ethylamino)nicotinoyl fluoride; 3-Pyridinecarbonyl fluoride, 6-chloro-2-(ethylamino)-; 1092523-22-2; 6-Chloro-2-(ethylamino)-3-pyridinecarbonyl fluoride; 2-Amino-6-chloro-N-ethylnicotinoyl fluoride; 6-Chloro-2-(ethylamino)pyridine-3-carboxylic acid fluoride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. Standard quality control includes identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specific impurities. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.