Description

5,6,7,8-Tetrahydro-1,6-Naphthyridin-2-Amine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate and research chemical. This compound is a critical building block in the synthesis of complex molecules, offering significant value in medicinal chemistry and drug discovery programs. It is primarily utilized by research institutions, pharmaceutical companies, and CROs/CMOs engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Chemical Biology Probes: Used in the development of tool compounds and probes for studying biological pathways and target validation.
• Process Development & Scale-up: Employed in route scouting, process optimization, and pilot-scale manufacturing for clinical trial material.
• Academic Research: Utilized in university and institutional labs for synthetic organic chemistry and pharmacological research projects.

Basic Information

Product Name	5,6,7,8-Tetrahydro-1,6-Naphthyridin-2-Amine Dihydrochloride
CAS No.	1092475-60-9
Molecular Formula	C8H13N3 · 2HCl
Molecular Weight	240.13 g/mol (for free base: 151.21 g/mol)
Synonyms	2-Amino-5,6,7,8-tetrahydro-1,6-naphthyridine dihydrochloride; 1,6-Naphthyridin-2-amine, 5,6,7,8-tetrahydro-, dihydrochloride; THN-2-Amine dihydrochloride; 5,6,7,8-Tetrahydro[1,6]naphthyridin-2-ylamine dihydrochloride; 1092475-60-9; 2-Amino-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride (1:2)
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrahydro-1,6-Naphthyridin-2-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF for moisture content, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.