Description

5-Bromo-2-Hydroxy-6-Methyl-4-(Trifluoromethyl)Nicotinonitrile is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound matters for its unique trifluoromethyl and bromo substituents, which are critical for modulating the physicochemical and biological properties of target molecules in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Institutional Research: Used in university and government laboratories for fundamental research in synthetic methodology and heterocyclic chemistry.

Basic Information

Product Name	5-Bromo-2-Hydroxy-6-Methyl-4-(Trifluoromethyl)Nicotinonitrile
CAS No.	1092352-76-5
Molecular Formula	C9H4BrF3N2O
Molecular Weight	293.04 g/mol
Synonyms	5-Bromo-2-hydroxy-6-methyl-4-(trifluoromethyl)nicotinonitrile; 5-Bromo-2-hydroxy-6-methyl-4-(trifluoromethyl)pyridine-3-carbonitrile; 3-Cyano-5-bromo-6-methyl-4-(trifluoromethyl)-2-pyridinol; 2-Pyridinol, 5-bromo-3-cyano-6-methyl-4-(trifluoromethyl)-; 5-Bromo-6-methyl-4-(trifluoromethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Hydroxy-6-Methyl-4-(Trifluoromethyl)Nicotinonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and compliance with REACH regulations ensures a reliable supply for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.