Description

5-Chloro-2-Hydroxy-6-Methyl-4-(Trifluoromethyl)Nicotinonitrile is a high-value, multi-functional heterocyclic building block featuring a chlorinated, trifluoromethylated pyridine core. This compound matters for its role as a critical synthetic intermediate in the development of advanced active ingredients, where its unique substitution pattern enables precise molecular tuning. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a specialized monomer or additive in the development of advanced polymers, liquid crystals, or organic electronic materials due to its electron-withdrawing characteristics.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing chemical probes, enzyme inhibitors, or molecular tags to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Chloro-2-Hydroxy-6-Methyl-4-(Trifluoromethyl)Nicotinonitrile
CAS No.	1092352-68-5
Molecular Formula	C8H4ClF3N2O
Molecular Weight	236.58 g/mol
Synonyms	5-Chloro-2-hydroxy-6-methyl-4-(trifluoromethyl)nicotinonitrile; 5-Chloro-2-hydroxy-6-methyl-4-(trifluoromethyl)pyridine-3-carbonitrile; 3-Cyano-5-chloro-6-methyl-4-(trifluoromethyl)pyridin-2-ol; 2-Pyridinol, 3-cyano-5-chloro-6-methyl-4-(trifluoromethyl)-; 5-Chloro-2-hydroxy-6-methyl-4-trifluoromethylnicotinonitrile
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Hydroxy-6-Methyl-4-(Trifluoromethyl)Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.