Description

5-Chloro-6-Cyclopropyl-2-Hydroxy-4-(Trifluoromethyl)Nicotinonitrile is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a nicotinonitrile scaffold with chloro, cyclopropyl, hydroxy, and trifluoromethyl substituents, enabling precise molecular modifications. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Serves as a critical building block for developing next-generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Used in the development of specialty chemicals, advanced polymers, and liquid crystal materials due to its rigid, substituted pyridine core.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tag in the study of biological pathways and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific, multi-step synthetic routes.

Basic Information

Product Name	5-Chloro-6-Cyclopropyl-2-Hydroxy-4-(Trifluoromethyl)Nicotinonitrile
CAS No.	1092352-56-1
Molecular Formula	C10H6ClF3N2O
Molecular Weight	262.62 g/mol
Synonyms	5-Chloro-6-cyclopropyl-2-hydroxy-4-(trifluoromethyl)nicotinonitrile; 2-Hydroxy-5-chloro-6-cyclopropyl-4-(trifluoromethyl)pyridine-3-carbonitrile; 5-Chloro-6-cyclopropyl-2-oxo-1,2-dihydro-4-(trifluoromethyl)pyridine-3-carbonitrile; 3-Cyano-5-chloro-6-cyclopropyl-4-(trifluoromethyl)pyridin-2(1H)-one; 1092352-56-1; Nicotinonitrile, 5-chloro-6-cyclopropyl-2-hydroxy-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Chloro-6-Cyclopropyl-2-Hydroxy-4-(Trifluoromethyl)Nicotinonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.