Description

5-Bromo-6-Cyclopropyl-2-Hydroxy-4-(Trifluoromethyl)Nicotinonitrile is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound matters for its unique trifluoromethyl and bromo substituents, which are critical for modulating the physicochemical properties of target molecules, such as metabolic stability, lipophilicity, and binding affinity. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and antiviral programs.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides and fungicides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Material Science Research: Serves as a precursor for functionalized pyridine derivatives used in organic electronic materials and liquid crystals.
• Chemical Biology Probes: Employed as a building block for creating molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex, high-value target molecules for client projects.

Basic Information

Product Name	5-Bromo-6-Cyclopropyl-2-Hydroxy-4-(Trifluoromethyl)Nicotinonitrile
CAS No.	1092352-29-8
Molecular Formula	C10H6BrF3N2O
Molecular Weight	307.07 g/mol
Synonyms	5-Bromo-6-cyclopropyl-2-hydroxy-4-(trifluoromethyl)nicotinonitrile; 2-Hydroxy-5-bromo-6-cyclopropyl-4-(trifluoromethyl)pyridine-3-carbonitrile; 5-Bromo-6-cyclopropyl-2-oxo-1,2-dihydro-4-(trifluoromethyl)nicotinonitrile; 3-Cyano-5-bromo-6-cyclopropyl-4-(trifluoromethyl)-2(1H)-pyridinone; 1092352-29-8
EINECS	Contact for details

Quality Control

Our 5-Bromo-6-Cyclopropyl-2-Hydroxy-4-(Trifluoromethyl)Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.