Description

4-Iodo-Benzofuran-2-Carboxylic Acid Ethyl Ester is a versatile and high-purity iodinated heterocyclic building block essential for advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of complex molecules, particularly in pharmaceutical research and material science. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the iodine atom can be leveraged for further functionalization or as a structural component.
• Material Science: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to the benzofuran core.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Ligand and Catalyst Development: Utilized in the synthesis of specialized ligands for catalysis or as a scaffold for metal-organic frameworks (MOFs).
• Academic & Contract Research: Employed in university and CRO laboratories for method development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	4-Iodo-Benzofuran-2-Carboxylic Acid Ethyl Ester
CAS No.	1092351-95-5
Molecular Formula	C11H9IO3
Molecular Weight	316.09 g/mol
Synonyms	Ethyl 4-Iodobenzofuran-2-carboxylate; 4-Iodo-2-benzofurancarboxylic Acid Ethyl Ester; 2-Benzofurancarboxylic Acid, 4-Iodo-, Ethyl Ester; 4-Iodo-1-benzofuran-2-carboxylic Acid Ethyl Ester; 1092351-95-5; AI3-28500; SCHEMBL23346895; ZINC000253909977
EINECS	Contact for details

Quality Control

Our 4-Iodo-Benzofuran-2-Carboxylic Acid Ethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.